We released Oracle Application Management Pack 184.108.40.206 last year. At that time, that release was certified with the base release of Oracle Enterprise Manager 12c.
Oracle Application Management Pack 220.127.116.11 is now certified with the latest Oracle Enterprise Manager 12c patchset: version 18.104.22.168 (a.k.a. "EM 12c Release 3" or "12cR3").
Upgrading from previous Enterprise Manager releases
Customers upgrading to Enterprise Manager Cloud Control 12c Release 3 from Enterprise Manager 10g Release 5 or Enterprise Manager 11g Release 1 must follow Section 5 Step 6 in this document:
Understanding our product names